Alex Lee

speaker
101 appearances 1 recordings 1 series first heard Oct 2022 last heard Oct 2022

Alex Lee’s voice in public audio — every appearance, attributed to the second.

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Thank you.
Happy to be here.
Sure.
So for diabetes example, um
You know, a lot of the diabetes prevention that the um controlling blood sugar works for is for things like preventing um chronic kidney disease or dialysis.
And those have a very, very long time horizon.
You know, someone who's healthy in their 60s and just got diagnosed with diabetes, yeah, they might benefit if they have a very long life expectancy to prevent that decline in kidney function.
But for someone who's already um, you know, has
Significant cardiovascular disease or other comorbidities, they might have a shorter life expectancy.
And so the benefit that they would get from lowering their blood sugar from, say, an A1C of eight to an A1C of seven.
That might that might improve their kidney function if they lived another twenty years.
But if they're not going to live another twenty years, then there's no point in giving them the extra medication for um lowering their A1C.
And so I think that's um
A great example of how time to benefit is really important in terms of comparing that with the expected time uh life expectancy that a patient has.
One reason to use prognostic indices is um really to kind of standardize, you know, prognosis across clinicians.
I think there can be a lot of variability across different clinicians, maybe you know, their experiences, um, you know, what sort of comorbidities they see, maybe an endocrinologist has a different opinion about what life expectancy might be compared to a geriatrician.
um, you know, compared to an oncologist.
Um, and maybe they are all even seeing the same patient, but they could have different ideas of what that prognosis looks like.
Um, so that's one reason.
I think also there's been studies that show that um clinicians often have a biased view of what prognosis, how long people have to live.
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