Andrea Kwakowsky

speaker

106 appearances 1 recordings 1 series first heard Jun 2026 last heard 28 Jun

Andrea Kwakowsky’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jun 2026 with 1.

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Futureproof with Jonathan McCrea · The Internet of Animals · 28 Jun 2026 podcast

I should mention that in the genetic code, there is a repeat in the Huntington's disease, in the Huntington gene.

And then the number of repeats, they will determine when the person might develop the disease.

So in very rare cases, the disease onset can be when someone is in their 20s.

But these are extreme cases.

In that case, they might carry like 60 or even higher repeats of this gene, of this expansion.

If the person carries 36 repeats, it's very likely they will develop, but everyone who carries 40 or above, they will develop the disease during their lifetime.

But even in identical twins, the onset of the disease is not the same.

So this complicates the situation and tells us that environmental factors and lifestyle can

Most likely, and maybe even other disease processes, you know, other disorders that might affect the person, they can influence the disease onset.

Usually, people with Huntington's, they will have earlier onset than those with Alzheimer's, but still the risk factor is age.

So as we are aging, there is more likely that people will develop Huntington's disease if they carry the genes.

Yes, exactly.

And if someone has this very early onset disease, they might die really, the disease progression might be really fast.

So they might live with it for a few years only.

If it develops around midlife, again, it's very variable.

But some people live with it like for a decade or longer.

But as you mentioned, some people will develop the disease about their 70s, 80s.

In Huntington's disease, we know that there is the gene mutation and that's the main cause of the disease.

But what exactly this mutation is causing, what kind of changes in the body and in the brain, that's not so obvious still.

We know that it leads to the accumulation of the mutant Huntington protein.

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