Andrew Buchanan
speaker
155 appearances
1 recordings
1 series
first heard Jun 2026
last heard 22 Jun
Andrew Buchanan’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jun 2026 with 1.
Appearances
that could have put together a workflow.
How is that QC'd?
It's important that there really are sanity checks to ensure the validity
And kind of prevent any confabulation.
Uh
And the reality is that biology is really complicated, especially immunology.
So having the most relevant data to build your CTP might not actually be possible.
Yeah, so the AI tools really have revolutionized the kind of structure prediction front.
There was rightly lots of excitement around the Nobel Prize in twenty twenty four.
Mm big claims were made for all this.
But they're not really in the context of real world drug discovery.
And in many ways we still have a lot to do to finish the job and bring new drugs forward to patients.
So if we go back to thinking about it in a people focused C D T P thinking
The AI tech has to provide some advantage alongside the brilliant empirical methods which
that have filled the biotech pipelines really with new antibody medicines for the past thirty years.
And the highest bar that's set is really the ability to do epitope specific antibody discovery.
As the epitope drives the antibody mechanism of action, its affinity, its specificity, and there have been a number of headline nature series and bioarchive papers using techniques such as RF antibody, chai bolts, Nabla's jam.
They demonstrate the potential of this structure driven strategy.
But how well that's being deployed and incorporated into the biotech and pharma pipelines is hard to tell.
That's why conferences and other working groups are super helpful to talk through what's working well, what's still a challenge.
Showing 61–80 of 155 · page 4 of 8
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