Andrew Buchanan

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155 appearances 1 recordings 1 series first heard Jun 2026 last heard 22 Jun

Andrew Buchanan’s voice in public audio — every appearance, attributed to the second.

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Talking Techniques · AI & Antibodies miniseries | Designing smart antibodies in the age of AI · 22 Jun 2026 podcast

I think finally

Building and be able to share pre-competitive data sets would help enormously.

And we see that in efforts such as the AI and antibody competition.

There are federated learning initiatives like AS AISB and FAIT.

There's actually recently been a generous philanthropic data provision from um the Gates Foundation with the work they did with ChiMad Sonofi.

And now even this today, uh Amazon have just dropped a very large developability data set.

So again, a new provider that you wouldn't have expected to be providing data, but it it opens new windows in where the data will come from.

Hm, yes.

Well you actually need an AI agent to help you track the number of peer reviewed, bioarchive and conference abstracts on this topic in the last

Few years.

But in the broad sweep there have been some great technological proofs progress on the Epitope specific de novo design.

Uh affinity predictions are still hard, but groups are bringing together machine learning and physics based scoring, which is helping.

But they're all still at the early stages of being incorporated into real world drug discovery platforms.

And if you can recall in that paper in MABS that we had a figure three, which is like a traffic like view.

So I think some of the top half of that would definitely now be greener.

But the bottom half remains uh stubbornly red around aspects of developability, PK and imogenicity.

But I was excited to read a paper on the bioarchive this morning.

It was from a group in Seoul National University and a company called Protein A.

And they've just published a paper that provides the most concrete evidence yet that the AI antibodies field is bottlenecked by data and not the algorithms.

So in this paper they actually describe Protein A's what they call the SPID platform.

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