Benjamin Thompson
speaker
746 appearances
10 recordings
1 series
first heard Jul 2026
last heard 2 Sep
Benjamin Thompson’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 10 in all, peaking in Jul 2026 with 5.
Appearances
These studies are pointing to the existence of a great variety of molecular maintenance workers that make for a long and healthy life.
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A master regulator of repair discovered in twenty twenty three also suggests that these fix it systems could be enhanced in unison.
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Such findings come alongside a booming interest in longevity more generally, propelled by biotechnology companies, health influences, and governments overseeing aging populations.
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If you can reduce DNA damage, you would probably have a dramatic effect on the aging process, says Paul Robbins, who directs the Nathan Schock Center on Genome Integrity and Aging, which opened last year at the University of Minnesota in Minneapolis.
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Quote There are tricks that we can do, but it's not simple, end quote.
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Despite having such a big job, DNA is remarkably fragile.
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Left unrepaired, its many breaks, kinks, lost bases, and cross links can physically block the processes necessary to make proteins or to form new cells.
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That means that for life to get anywhere with DNA as a blueprint, maintenance is essential.
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DNA damage has been the fundamental problem at the origin of life, says Bjorn Schumacher, a geoscientist at the University of Cologne in Germany.
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Cells have an ancient and varied toolkit.
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There are six major DNA repair systems, a few smaller ones and probably some that haven't been discovered, Schumacher says.
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Different systems respond to different forms of damage.
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If a single DNA base, such as guanine gets oxidized, an oxygen atom gets added to its structure, then a process known as base excision repair can make the fix.
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This removes and replaces one base at a time.
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Nucleotide excision repair by comparison removes a couple of dozen nucleotides along a single strand at once, a heftier fix often triggered by UV damage.
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The repair systems tend to require several steps.
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They call on many proteins and overlap with one another, with one system jumping in if another is not active.
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Some are sloppier than others, prone to introducing errors as they make their fixes.
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One way to repair a break that spans both strands of the DNA double helix, for example, is homologous recombination.
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This uses an intact DNA strand to serve as a template and is generally accurate.
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Showing 21–40 of 746 · page 2 of 38
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