Benjamin Thompson
speaker
746 appearances
10 recordings
1 series
first heard Jul 2026
last heard 2 Sep
Benjamin Thompson’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 10 in all, peaking in Jul 2026 with 5.
Appearances
Non homologous end joining, however, another way to fix double strand brakes, doesn't require a template and does a more slapdash job by fusing broken ends together.
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This sometimes introduces errors that can lead to cancer driving mutations, but a repair with a small risk of mutation is better than no repair at all.
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Many genes are involved in these repair systems.
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Some researchers suggest that ten percent of the genome plays a part in genome maintenance.
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In searching for ways to enhance repair, quote, this complexity has always been a limiting factor, says Schumacher.
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When researchers have tried to enhance repair directly by switching on one repair system or overexpressing a repair enzyme, the effect has often been limited.
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Or worse, it has thrown the whole process out of balance.
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One of the big challenges is that there are so many repair pathways, says Anielle Sweer, a molecular geneticist at the Memorial Sloan Kettering Cancer Center in New York City, who studies DNA repair in the context of cancer.
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At the moment we do not know which DNA repair can be boosted or should be boosted, she says.
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The animal kingdom might provide clues.
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Scientists are studying species with long, relatively cancer free lives, including naked mole rats, greenland sharks, elephants, bats, and lobsters.
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For one of her latest projects, biologist Vera Gorbanova at the University of Rochester, New York, and her team chose Bowhead Whales.
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These marine mammals weigh in at more than eighty thousand kilograms and glide and dive through frigid Arctic waters year round.
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Although the whales can live for more than two hundred years and have a thousand times as many cells growing and dividing as humans do, cancer rarely creeps in.
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In a study published last year, Gorbanova and her colleagues went looking for reasons why bowhead whales are resistant to cancer.
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They thought they might find extra copies of genes that helped to suppress and kill cancers, but instead they found that whale cells had very accurate double strand brake repair.
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The whales don't need to kill the cells, they just don't let cells mutate as far, Gorbanova says.
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A protein called cold inducible RNA binding protein that helps cells to survive cold related stress seems to have a role.
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When expressed in human cells, the whale protein increased two types of double strand brake repair.
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That finding chimes with a study from twenty nineteen in which Gorbanova and her colleagues looked at eighteen rodent species with varying lifespans.
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Showing 41–60 of 746 · page 3 of 38
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