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Charlotte Bunne

👤 Person
104 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Thanks for having me.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So I did my postdoc with Aviv Regev at Genentech and Yuri Leskovich at CZI.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

And Yuri was part of the residency program of CZI.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

And so this is how we got involved.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

And Yuri had also prior work with Steve on the universal cell embedding.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So this is how everything got started.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So I think, I mean, one core idea of building this AIVC is that we basically can leverage all experimental data that is overall collected.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So this also goes back to the point Steve just made.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So meaning that we basically can integrate across many different studies data because we have AI algorithms or the architectures that power such an AIVC are able to integrate basically data sets on many different scales.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So we are going a bit away from this dogma.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

I'm designing one algorithm from one data set to this idea of I have an architecture that can take in multiple data set on multiple scales.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So this will help us a bit in like being somewhat efficient with the type of experiments that we need to make and the type of experiments we need to conduct.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

And again, what Steve just said, right?

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Like ultimately we can very much steer which experiments we need to even conduct.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

data sets we need to collect.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Currently, of course, we don't have all the data that is sufficient.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

I mean, in particular, I think most of the tissues we have, they are healthy tissues, right?

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

We don't have all the disease phenotypes that we would like to measure.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Having patient data is always a very tricky case.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

We have

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