Dan Belsky
speaker
80 appearances
1 recordings
1 series
first heard Jul 2026
last heard 17 Jul
Dan Belsky’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
I mean, this is a challenge the field has been wrestling with for a number of years, that we have many different measurements of aging.
They don't agree.
There's a theory that they all mean something important, and we need to look to different clocks for answers to different questions.
I think from the perspective of the patient, the consumer, the person who's out there getting their own tests, some of these clocks are inherently more interesting than others, and it makes sense to attend to those ones.
And the ones that I think are relatively more interesting are the ones that have shown they are predictive of morbidity, disability, and mortality.
I want to interpret the epigenetic clock that has been shown to be predictive of the outcomes that I care about.
So there are some clocks that are more trustworthy than others, but even those clocks won't necessarily agree with one another.
And that's part of the challenge in entering into, as a consumer, a biomedical field which is still in the research phase.
I think that's generally right.
If you are seeing consistent signals across the handful of well-validated epigenetic clocks and perhaps consistent signals in clinical measurements that your physician or other health care provider might take of you, that's going to be a really positive sign.
But if you're seeing different clocks giving you wildly different results, it may be the case that those measurements are not going to be highly interpretable for you.
What do we know?
Not that much yet.
We have a lot of accumulated knowledge about how to live a long, healthy life.
And I wish I had big update to give you on what to do.
But the answer is still pretty much the same as it's always been.
We now have a handful of randomized clinical trials that have evaluated epigenetic clocks.
The first of those was the CALERIE trial, this caloric restriction study that we reported on and observed effects, not on grim age, but on Dunedin pace.
Subsequently, there have been two further clinical trials published.
One called DoHealth is the Swiss site of a larger European study that was testing the effects of nutritional supplements, so vitamin D, omega-3s, and also exercise in healthy older people.
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