Darren Saunders
speaker
165 appearances
2 recordings
1 series
first heard Jul 2016
last heard Sep 2016
Darren Saunders’s voice in public audio — every appearance, attributed to the second.
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Another part of the cell broken down and then remade into new proteins.
Or it can help the cell signaling, it can help cells switch on the way that they communicate with each other and communicate with inside the cell.
And people, not just me, lots of people have been interested in this system for a very long time.
It was discovered 30, 40 years ago, and the guys that discovered it won the Nobel Prize.
And it's important in the way your immune system works, it's important in the way your brain works, basically everything.
Mm.
work in cancer, what role were you thinking the ubiquitin
Right.
So it turns out that to be a cancer cell is a really stressful situation.
So you have extra copies of DNA floating around, you've got mistakes in the genome, the metabolism of the cell has kind of gone out of control.
And in order to deal with that, the cell needs to be able to handle this stress.
Now we call that proteostasis.
It's a big word, but it basically means maintaining normal protein chemistry, if you like.
And one of the way the cells do that is using this ubiquitin system.
And so for a long time people have been looking at this system as a therapeutic target.
And there are therapies out there in the clinic that target this.
So there's a drug called Velcade, which is used for multiple myeloma.
And basically the way that works is that if you take a cancer cell that's very stressed out and you take away its capacity to respond to that stress, the cancer cell dies.
And now we're looking at that in a whole bunch of different contexts in cancer.
What other context here?
Showing 81–100 of 165 · page 5 of 9
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