Darren Saunders
speaker
165 appearances
2 recordings
1 series
first heard Jul 2016
last heard Sep 2016
Darren Saunders’s voice in public audio — every appearance, attributed to the second.
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So so we think most cancer cells do this.
The way we're approaching it is we're able to use a method that lets us look at all of the proteins in the cell that are flagged with this little ubiquitin tag.
So we can do it sort of systematically.
We smash the cells up or we smash up some tissue and we run it through a machine called a mass spectrometer, which is able to measure things very accurately.
And that gives us a sort of a map, if you like, of what's being ubiquitulated or flagged with this little ubiquitin protein.
at any one time.
And what we're interested in is whether or not we can find specific proteins in the cell that we have drugs against that we can switch off and try and kill the cell.
That's the the kind of principle behind it.
It really is.
It's a really interesting one.
This came about literally from a mountain biking trip.
I was away mountain biking with some mates.
You know, some of my mates are other medical researchers.
They work in other fields, in this case, neuroscience.
And we literally got chatting over a mountain bike ride about this field that, you know, we started to see some crossover in what we were working on and what we were talking about.
And that just grew into now a really serious collaboration.
We've managed to get funding for it.
And basically what we're doing is using the approach.
approach that we've taken in cancer to understand this system.
And start to look at it in a neurodegeneration context.
Showing 101–120 of 165 · page 6 of 9
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