David Currow
speaker
250 appearances
1 recordings
1 series
first heard Jan 2020
last heard Jan 2020
David Currow’s voice in public audio — every appearance, attributed to the second.
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Appearances
Well, again, if it's just PRN, then you're not going to have a background level.
If you're using it orally, it's going to be some time before there's an effect.
So particularly if you're using it
for emergent breathlessness, or even for planned function, you know, the peaks are 30 to 60 minutes after you've taken it.
And if there's no background on which to build, you're really starting from zero each time.
So, you know, in chronic, I think the point here is that chronic breathlessness is with people all of the time.
I really like the Australian author Tim Winton's view on this.
You know, you never think of breathlessness until it's all you think about.
And I think we underestimate the lived experience.
And so much of the work that's been done qualitatively
has been about the intensity and the constancy of that lived experience, which you and I, for some reason, just don't see in the same way that we see chronic unremitting pain.
Well, we can go to the bottom line.
But look, this was a multi-site study.
It was a placebo-controlled study.
It was still felt by the investigational review boards, institutional review boards, that a placebo arm was justified.
But unfortunately, they also insisted that –
As needed, immediate release morphine solution was available to all participants.
And that in itself is problematic.
And that was an IRB requirement.
It wasn't in the original design.
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