David Currow
speaker
250 appearances
1 recordings
1 series
first heard Jan 2020
last heard Jan 2020
David Currow’s voice in public audio — every appearance, attributed to the second.
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Appearances
The study had a primary endpoint at seven days, and we believe that pharmacokinetically steady state is there by somewhere between 45 and 60 hours.
But the pharmacodynamic effect we've previously published is still having an impact perhaps five or six days after successful dose increment.
That is that people's breathlessness is continuing to improve.
out to five or six days.
So by seven days, we're hoping that we're in a state that is optimizing the reduction in people's chronic breathlessness.
It was otherwise a relatively straightforward study.
We measured the primary outcome as breathlessness now, and we'll return to that in a minute.
We measured it on a visual analog scale with a
twice daily diaries for that, as well as worst, best, and average breathlessness over the previous 24 hours.
So this was a large study.
In fact, this study is larger than several of the meta-analyses about which we've spoken today.
So it was a substantial piece of work and a huge commitment on behalf of pulmonologists, palliative care physicians,
cardiac physicians and oncologists.
So this study started with a population saying it doesn't matter what the underlying etiology is, but if you have a modified Medical Research Council scale of three or four, you are eligible for the study.
It's important also to note that the study actually started as a three-arm parallel arm fixed-dose study with oxycontin
So extended release oxycodone three times a day at an equivalent dose.
That arm was truncated a little early because of recruitment challenges.
And that paper has been published separately.
And interestingly, that oxycodone paper is strongly negative in all of the primary and secondary outcomes.
Yep.
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