David Fagenbaum
speaker
271 appearances
3 recordings
2 series
first heard Dec 2024
last heard 28 Feb
David Fagenbaum’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Feb 2026 with 1.
Appearances
Now, this is an example where we discovered a repurposed treatment, but sometimes we actually uncover matches that already exist, they're just not being utilized.
For example, one day I was reviewing through the results of our platform, and I came across Leucovorin, this cheap vitamin derivative where there was data to suggest that it could help to improve speech in a subgroup of patients who have antibodies against the folate receptor, so therefore they don't get folate into their brain.
I was so amazed to learn about the work being done by Richard Frye.
He had done the first of three randomized controlled trials that showed a benefit for this medicine in this subgroup of patients.
And I learned about Mason, who was nonverbal for three years, and within three days of starting Luke of Warren, began to say his first words.
And then, yes, it's incredible.
And then Ryan was basically nonverbal for five years and had never shared a complete thought or feeling with his parents and was told by doctors that he probably would never share a feeling with them.
Within two weeks of starting Luke of Warren, he turned to his dad when he was leaving for work and said, Daddy, I love you.
It's just incredible.
It's just incredible.
What's also incredible is that there's a blood test that can help to identify kids like Mason and Ryan that is available to help to find these patients, and it's still barely being utilized.
This is why we started EveryCure, to unlock these hidden treatments and make sure they reach every patient they can possibly benefit, like we did for Joseph, who was dying from Pohm syndrome, which is a rare cancer, and on his 30th birthday was saying goodbye to his girlfriend Tara because his doctor had tried everything that he thought was possible.
We recommended three drugs that are commonly used for multiple myeloma, which is similar to poem syndrome, in a last-ditch effort to save him.
And amazingly, they worked.
Instead of planning Joseph's funeral service, Joseph and Tara are planning their wedding day, and Joseph's here with us today from Seattle.
Joseph, I'm so glad you're here.
Woo-hoo!
How many of us have sat with someone we loved like Caitlin did and like Tara did and like Mason's parents did and heard the words, we've tried everything, there's nothing more we can do?
What if we haven't tried everything?
What if there's a solution out there for them and thousands, maybe even millions more with their disease?
Showing 221–240 of 271 · page 12 of 14
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