Derek (More Plates More Dates)

But the reality of what makes this even worse is your SHBG levels will increase year over year proportionally faster, thus making the velocity of free testosterone decreases dramatically more so proportionally.

So even though total test decreases by 1% a year, your free test will decrease by up to 2% per year.

And that's the one that you need to like do stuff in the body through like freely circulating activity.

So...

it's very important and very relevant for dictating what activity you have in different tissues in the body because it's ultimately the only one that can actually bind to the receptor and do what it's supposed to do so the shpg levels will be dictated by age will be dictated by liver health to some extent will be dictated by other medications especially oral formulations um

Insulogenic signaling as well, hugely implicated.

If you're on a ketogenic diet, you can absolutely expect your SHBG levels to be through the roof and your free test to be much lower.

So carnivore diet guys, there's a reason they eat fruit now.

It's because their free test levels were all shit and their total test levels were high and they thought it was fine.

But in reality, they had like borderline hypogonadal free test levels often because they were overlooking the fact that insulogenic signaling is needed to actually get SHBG to a meaningfully reasonable level for a male.

Yeah.

And these binding proteins also exist for other hormones in the body because they all function in similar ways through cargo systems and transport mechanisms in the body.

Like you will have binding proteins for IGF-1.

You'll have binding proteins for thyroid hormones.

Like it's not uncommon to see people with like normal on paper levels for certain hormones.

But then when you dig deeper, all the free hormones are like normal.

proportionally horrible because they're all about like the the total production looks okay but it's because it's factoring in all these like bound up hormones that are in use like unusable essentially

Like, I mean, would you say that's... It depends on the person and lifestyle.

So, but yeah, probably, especially among women, because, you know, a lot of them are... You only have so much androgens to work with to begin with.

Like, your production is, you know, a tenth of males, typically.