Derek (More Plates More Dates)

Sound to, uh, it's worth being cautious and aware of all this stuff, but like, it's certainly not to don't dissuade yourself out of like fixing your levels too.

Like it's critical that you have adequate hormone production, similar to women in menopause.

Like the, the benefit outweighs the risk.

like essentially every single time, essentially.

And you just have to be responsible, your approach to what that is.

Okay.

So then circling back to administration, like the ideal way to go about it.

I can say off the rip, I would not do pellets.

I would probably not do androgel if you're a male.

If you're a female, it's a bit different, which we can get into.

The creams through compounding pharmacies, that's probably the only, like, tolerable way you're going to have something that you can apply scrotally to get the ideal absorption pharmacokinetic profile that would be reflective of something that's, like, more natural.

So, like, that is probably on paper arguably the best way to go about it.

It's just not necessarily something everyone wants to do.

But it...

it works well and it will get you to the levels that are great and look pretty physiologic and like kind of reflect the pulsatile diurnal nature of normal testosterone secretion and it's also converting like locally like in the area you would actually be producing it too like there is a local effect too through like five alpha reduction in the skin and stuff like that um

Which can result in, that's why monitoring like DHT and some of this other stuff can be important, but that's like a whole more nuanced discussion.

But in general, the cream scrotally is reliable, good, produces a very favorable outcome, and a lot of guys will be quite happy with that method.

The other method that I would say is worth considering and like the typical one that most guys do is injection, which it's a bit more predictable typically in terms of like what you're going to get out of it.

In terms of adherence, it's a lot easier because you don't have to shoot it daily.

You can also modulate the release pattern of it through either the ester.