Derek (More Plates More Dates)

Yeah, I think the majority of the benefit is likely mediated via ensuring adequate absorption of the drug because...

when you do microneedling on its own, like versus minoxidil on its own versus microneedling plus minoxidil, like it's not a comparable outcome in terms of like you would expect the microneedling alone group to be very significant if it was recruiting some sort of local growth factors that were dramatic.

It seems more like it's probably in ensuring you're actually getting this to where it was supposed to go to begin with, but maybe wasn't getting fully assimilated, which is fine if that's what it does.

It's just like,

That's what some people need in order to get the absorption.

But it could be like the difference of 4X the results I've seen in some studies.

Neurological, potentially through the balance of like neurotransmitters and zeolitic versus like.

there's a whole rabbit hole to go down of like inhibition of allopregnenolone, which is thought to be the main thing implicated in postpartum depression, being deprived of it.

And there's a literal pharmaceutical that was developed to like manually restore that.

And women that just had birth and have postpartum depression, and it seems to be efficacious.

And seemingly by inhibiting five alpha reductase, you may be inhibiting that like GABA ergic signaling through that, like anxiolytic kind of like calming thing, uh,

molecule, essentially.

And it results in kind of like a... It depends on the person.

It can get pretty severe, I'm sure you've seen.

Or at least, you know, depending on if you've seen the podcast where people talk about it or not.

You'll never hear about post-dutasteride syndrome, though.

Even though it's a way more potent drug.

Because it's largely a media-driven construction.

it's not to say it's not real.

There's definitely side effects from these drugs, but like, there's a huge nocebo effect that comes with these drugs where, you know, I have friends who get on it and they're like, dude, I swear, like, you know, my penis is not working like it used to.