Derek (More Plates More Dates)

And I know a lot of individuals that I respect in, you know, the anti-aging longevity community who also use it and think that it's, you know,

a reasonable enough risk profile for them.

And that's not to say that I, that means I endorse it or I don't endorse it.

I just use it and I've been okay to date, knock on wood, because maybe something will happen.

I don't know.

Yeah, because like these are drugs that are used for benign prostatic hyperplasia and even at dosages up to like 2.5 milligrams daily of dutasteride has been used.

With great success with individuals with like no, you know, like a minority of prevalence of side effects and like they're relatively minor from what I've seen.

The longest study that I know of off the top of my head, there's definitely studies assessing follow ups of individuals who've been on it for like a decade plus, I think.

If any, this is going to be a controversial one, but my speculation is that if anything, these would net.

would increase your longevity because they're decreasing androgenic stimulation significantly.

Because DHT is literally the most androgenic hormone in your body.

And if you're inhibiting it and you're just left with the testosterone and the anabolic activity, because DHT is entirely inactivated in muscle tissue.

So you get no muscle growth benefit.

Graded dose response studies using Dutasteride alongside testosterone, even at super dosages, the Dutasteride getting wiped out had no impact whatsoever on strength and muscular hypertrophy.

So like there's no benefit muscularly to DHT

in any capacity as an adult which is notable because a lot of people think their physique is going to deteriorate if they use one of these drugs not the case has no impact on it whatsoever so i would think especially somebody who's on trt and like candidly i don't take enough to put me at 400 total t like i take enough to put me at like 800 and like my free t is like the high normal

I think that the Dutasteride, probably whatever excitotoxicity or cardiotoxicity that I might otherwise be netting over into an area I wouldn't want, I would anticipate and speculate that the DHT reduction is probably inhibiting that whatever detriment might be there to some magnitude.

Could be wrong, but I have a net increase in intratissue aromatization from the inhibition of the 5-AR enzyme.

So in all the tissues that would otherwise be pro-longevity from estrogen locally, you're getting the proportional increase of 15% to 20% of intratissue estradiol.

And if you don't have any side effects from that, if anything, you would think...