Dr. Allen Bookatz

speaker

1,037 appearances 12 recordings 1 series first heard May 2026 last heard 3d ago

Dr. Allen Bookatz’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 12 in all, peaking in Sep 2026 with 4.

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Health Optimization Medicine Podcast · The Real Cause of Endotoxemia: Leaky Gut Explained | HOMe #023 · 19 Aug 2026 podcast

All right, Dr. matched

Yeah, let me try to take this from the top. matched

So, and I'll try to keep it in plain English for the listeners here. matched

So, the lining of your colon has a two-layer mucus coat built from a protein called MUC2. matched

Now, acromantia lives in the outer layer of this, and it makes its living breaking through those mucin sugars down into short chain fatty acids. matched

And those are acetate and propranate. matched

That breakdown isn't necessarily damage, it's actually the signal that tells. matched

goblet cells to lay down fresh, thick new mucus. matched

and robust. matched

Yeah, exactly right, Brumer. matched

So it's think of it like maintenance, not damage. matched

Think of it like uh, you know, you go to the dermatologist, you get your skin exfoliated. matched

You're not matched

damaging your skin, you're actually taking off that fresh layer so that you can trigger new cells to new fresh, you know, skin cells to form. matched

So in meanwhile, the other anaerobes that take that, there are other anaerobes in there that take acetate and propranate and it turns it into butyrate. matched

And remember, butyrate is the fuel that colonocytes cannot live without. matched

So normally the mitochondria in those cells, they pull butyrate in and they burn it through beta oxidation. matched

That burns up a huge amount of oxygen, which keeps inside the colon almost oxygen free. matched

So we call that actually physiologic hypoxia, something you don't necessarily want in your lungs and something we experienced when those of us on this call went to Tibet. matched

That's where the whole thing comes apart, Ted. matched

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