Dr. David Allison

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936 appearances 1 recordings 1 series first heard Mar 2026 last heard 31 Mar

Dr. David Allison’s voice in public audio — every appearance, attributed to the second.

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The Dr. Gabrielle Lyon Show · GLP-1 Drugs & Bariatric Surgery Explained by a Top Obesity Researcher | Dr. David Allison · 31 Mar 2026 podcast

Um, so I think that we've got some tremendous growth there.

I remember when leptin was first discovered 1994, I think, and very shortly thereafter, one of the group, and it was the Cambridge group, um,

came out with a paper showing treatment of, I forget if it was just one, one member of the family or a subset of a family who had very, very rare homozygous inactivating mutations for leptin production.

And they gave them exogenous leptin and great things happened clinically.

And I was so envious of them, of the research group.

Not because they got the paper in Nature.

That was true.

But because they were probably the first people in history to be able to honestly look a patient with obesity in the eye and say, I know why you're obese.

This was the inability to make leptin.

Right.

Exactly what it does sort of at, you might say, within the normal physiologic range among most of us who do make some leptin is...

I think still a little bit, you know, the jury's still out a little bit on that.

Exactly.

So there are many things that within the sort of, you might call the normal observed physiologic range, may not play such a big role or play the role we expect them to.

But when you get them out of the physiologic range, then they can be huge.

So GLP-1 is an example.

Within the normal physiologic range of what we endogenously produce, I think there's debate about this, but the question is how important is that?

How much difference does it make?

But when you give a GLP-1 agonist that has a long half-life, now you're getting to super-physiologic ranges.

In the case of a leptin-deficient human, you're getting into sub-physiologic, where you're having zero leptin, not low leptin.

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