Dr. David Perlmutter

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585 appearances 1 recordings 1 series first heard Jul 2026 last heard 15 Jul

Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Be Well by Kelly Leveque · 393: Alzheimer's Starts Decades Before Symptoms…Here's Why | David Perlmutter · 15 Jul 2026 podcast

There are a lot of inroads

that our microglia are sensitive to that will cause them to, the term is polarized.

Polarized means shift away from being supportive to a brain destructive environment.

And again, this is a big net to throw because it encompasses all

neurodegenerative conditions as well as various mood disorders.

So it explains why ketogenic diet, you brought it up, is effective in Parkinson's and Alzheimer's and being explored and showing early positive results in major depression as well.

How could this one approach have such a multitude of benefits because we're getting finally

to the root of what is causing the good brain to go bad.

And it gets to your original question.

Your very first question with me today was, what the heck is this thing about, oh, Alzheimer's is the accumulation of beta amyloid.

That'll fix the problem.

We can only get rid of that amyloid, problem solved.

And let's spend some time with that.

I sent it to him.

You know, we've known for an awful long time that there's more to the story than the accumulation of beta amyloid in the brain in terms of what is going on in Alzheimer's disease.

How can we say that?

Well, our suspicions began shortly after the late 1980s when people started to glam on to, oh, this is what it is, is beta amyloid.

if we can develop techniques to get rid of the beta amyloid problem solved.

Well, we began noticing that there are an awful lot of people out there who, when they have their PET scans for research reasons, have a lot of beta amyloid in their brains and are cognitively just fine, thank you very much, i.e.

they don't have Alzheimer's and yet they're accumulating this beta amyloid.

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