Dr. David Perlmutter

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551 appearances 1 recordings 1 series first heard Jul 2026 last heard 9 Jul

Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.

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The Human Upgrade: Biohacking for Longevity & Performance · The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498 · 9 Jul 2026 podcast

that monocycline can polarize the microglia to M1 or also, depending on how old you are, polarize redo revert them back to M two.

It can't it it's it's engine can be used for b uh both ways.

And uh there is a technique in dentistry where for re recession they are actually putting little pellets

or implanting doxycycline along the edges of the recession.

Interesting.

Hard to say what that's doing to the oral microbiome, what that's going to be like in the long run.

I mean, you're obviously gonna d dramatically reduce oral diversity.

Are you affecting

The bad guys, porful monas tengevalis, which isn't fundamental for cavity formation.

And are you at the same time affecting what we unpacked earlier, those bacteria that

are involved in processing a nit nitrate to nitrite.

Seems bad to have it in the mouth all the time.

It's interesting because monocycline is studied because of its in its ability to inhibit

The NLRP three inflammation and what that means in English is to reduce inflammation in the brain.

And in fact, many have uh there have been several studies looking at it as an interventional trial for um for even for Alzheimer's.

And and getting back to the work I mentioned earlier of Ruth Itsaki identifying a herpes simplex virus, there have been various recent interventional trials using antiviral, specifically targeting HSV type one, uh but they were in a they did not uh reach endpoints.

But it's been a great day.

Yeah, and I think y the broader picture is that brain inflammation is the fundamental mechanism.

It it incorporates this whole thing we're talking about, the shift of the immune cells, in all the bad things going on in your brain.

Yeah.

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