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Dr. Diego Bohórquez

👤 Speaker
956 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

You know, as what we detect of the world is just a very tiny little portion, right?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Even sight, you know, like we think we are looking for light, but I don't know what is happening behind my back.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

I trust that everything is going okay, right?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

So when we shut off these cells,

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

The animal, and as I usually say, became blind to the sugars because it's kind of like akin to having turned off the cells that are able to detect light, the wavelength of light, for us to be able to discern color.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And it's not that the animal is losing its memory because then if you remove the light and now the cells are functional again, then the animal again is able to distinguish one solution over the other.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And then we did a couple more experiments in there.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And what happens if we do the reverse?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

If we turn on the cells now?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And the fascinating thing is that when we turn on the cells, now the mouse will eat the sweetener as if it will be sugar.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Interesting.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

So here's another piece of information.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

If we will offer them water and we will turn on the cells,

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

the animal will drink the water as if it will be sugar, like it will be appetizing.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Even though it's just plain water.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Yes, and what is becoming very obvious is that the gut has this sense at the most basic level.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

What the senses are doing is calculating a couple of things.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

One is the salience of the stimulus.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

It's like how intense is the stimulus.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And the other one is the valence of the stimulus.