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Dr. Diego Bohórquez

👤 Speaker
956 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

I think that it goes from like two to seven fold.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

The likelihood that they become, they will develop alcoholism.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Really?

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Yes.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Because now the way that they describe it is like, well, you know, either before I didn't like wine.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And then now I, you know, after a few months of a surgery, I'll have one glass of wine.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And then all of a sudden I found myself going to two, three, four.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And then they will become either more sensitive.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

It's still not known the entire biology, but they will become either not only more sensitive, but more attracted to that type of stimulus.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

Yes, that's a complimentary question.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And in fact, when I got into studying in this field 15 years ago, the study among scientists in this area, glucagon-like peptide was already very popular in the study.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

In fact, in this area, people were very focused on the study of this peptide.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And they were very focused on the study of this peptide because it was one of the most potent stimulators of insulin release in the pancreas.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

After gastric bypass surgery, it will actually increase its amount in circulating levels.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And there were already some studies suggesting that the effect of this glucagon-like peptide, it was actually not through the circulation, but more in a localized action onto nerve fibers.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

especially of the vagus nerve.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

So there was already like some ongoing discussion about this.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

And certainly some of these enteroendocrine cells, these neuroendocrine cells, particularly at least in animals, I think it's more distal and in the digestive tract, that they do release this glucagon-like peptide.

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

One, in response to primarily like

Huberman Lab
Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

all of the macronutrients, but primarily sugar.