Dr Jay Jagannathan

speaker

177 appearances 1 recordings 1 series first heard Apr 2026 last heard 30 Apr

Dr Jay Jagannathan’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Apr 2026 with 1.

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The Dr Louise Newson Podcast · 62 – How hormones change your brain - Dr Jay Jagannathan · 30 Apr 2026 podcast

Estrogen has been shown to have a stimulatory role with neurotransmitters such as acetylcholine, with serotonin.

which dopamine, which are extremely important in terms of pleasure responses, in terms of alertness, in terms of activity.

And similarly, interestingly, progesterone levels have been shown to be correlated with GABA, which is an inhibitory neurotransmitter.

They've been shown to be related to things like relaxation and stuff like that.

So that combination of effects, clearly there is a relationship between hormonal changes and both the brain chemistry and the brain structure that happens after menopause that play a role in many of those symptoms you discussed.

Absolutely.

Yeah.

I mean, I think there's definitely a relation.

I think obviously the structural and the functional relationship play a role as well.

So I think these changes in neurotransmitters likely also play a role in terms of how the gray matter changes and stuff like that that we see as well.

And I think as the technology with subjective imaging improves, and I think that's the main thing we're seeing now in terms of MRI technology and the ability to kind of link with AI, the functional and the structural aspect, I think we'll see more of this data coming to light.

Right.

So any kind of symptoms that are different from the norm warrants further investigation, you know, irrespective of whether you're a male or a woman.

gender, race, whatever it is.

So it does.

I mean, I think one of the things we often see, you know, both you and I in our respective fields when people are embarrassed or shy or they've been told to brush these symptoms aside.

And obviously that's that's not the right answer.

I mean, I think nowadays one thing we have nowadays that we didn't have even 20 years ago is we have the ability to order testing and ability to

investigate these things much better than it was.

So I think that's the first part of it.

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