Dr Jay Jagannathan

speaker

177 appearances 1 recordings 1 series first heard Apr 2026 last heard 30 Apr

Dr Jay Jagannathan’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Apr 2026 with 1.

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The Dr Louise Newson Podcast · 62 – How hormones change your brain - Dr Jay Jagannathan · 30 Apr 2026 podcast

Specifically, as it relates to menopause, I mean, I think a lot of those changes, there are treatments.

I think the important part about it is that there are maybe not definitive solutions, but there are treatments such as hormone replacement, things like that, that can be a benefit.

Right.

So progesterone, yeah, I mean, it does have a protective effect on the brain.

And we talked about the relationship between that and GABA.

GABA, inhibitory neurotransmitter, you know, as I think we talked about before we got on the podcast, there's a lot of data that shows progesterone.

So when you look at brain tumors, meningioma specifically, benign brain tumors, up to 90% of them will have progesterone receptors.

And a progesterone receptor positivity in meningiomas has been shown to be correlated with a decreased risk of recurrence.

So there is positive effects of progesterone from that standpoint as well.

I do think you're right in terms of synthetic progesterone, especially that is a concern because obviously, you know, we know that there may be enough variation in terms of the receptor itself that maybe in terms of how it binds to the receptor might be different or might bind to a different receptor site.

Obviously, these are speculative things I'm saying, but it may have a different effect from a natural progesterone that maybe has a protective effect.

Probably not enough.

You know, I mean, I think the problem, you know, and I feel like neurosurgery, you're so focused on the technical aspect of things, you know, the general part.

But, you know, one question I have for you is that some patients I've talked to or some physicians I've talked to dealing with patients who have these symptoms, these perimenopausal symptoms, advocate early replacement estrogen.

They say if you wait longer, the effectiveness can go down.

Is that something you see in your clinical practice?

Okay, okay, sure.

And yeah, I think on that note, the other area that we deal with from a neurosurgical perspective is the effect of these hormones on the spine, right?

And there's a lot of data when it comes to things like back pain, osteoporosis, things like that, that I see kind of later on in the course, where obviously these are factors that you have to take into account with respect to hormone replacement therapy.

In particular, as it relates to the perimenopausal period, you know, the protective effect of estrogens within in terms of bone density and things like that, as well as changes in estrogen can affect ligamentous factors and stuff like that can lead to things like back pain and things like that in patient tests.

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