Dr. Jeff Bland
speaker
312 appearances
4 recordings
1 series
first heard Nov 2024
last heard Jun 2025
Dr. Jeff Bland’s voice in public audio — every appearance, attributed to the second.
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Appearances
So we're seeing this sort of one, on one hand, this rising understanding of chronic disease being an inflammatory state, aging itself being an inflammatory state if we don't properly understand how to regulate that. And at the same time, we're seeing this rise in
our ability to have really granular understanding diagnostically of what's happening at the gene level, at the epigene level, at the immune cell level, and ways that we never did before that are kind of uncovering relationships and connections and things that help us to understand how to modify our lifestyle and our diet
and our habits so that we can properly regulate our immune system so it does the right thing, which is to fight foreign invaders when we need it to, but not to do the wrong thing, which is to be overactive in a state of chronic disease or an autoimmune disease or an allergy, right? We don't want that. So how do we sort of start to think about the immune system?
Sort of take us through sort of a beginner's level, the immune system, from the types of immune systems we have to what they do and to how they... they influence these chronic diseases.
What you're saying is we need to move from an inflammatory lifestyle to an anti-inflammatory lifestyle. And we're going to unpack what that is.
So essentially in English, that means when you take a sample of blood, the thing that we're measuring to look at your biological age is the DNA in your white blood cells, which is your immune system.
Call it fire in the belly. It's like the fire in your fat cells in your belly that send a spreading fire across your body.
Yeah.
So are you saying that the reason for the systemic inflammation throughout our body, the silent killer, this quiet inflammation that is not like the inflammation we learned about in medical school where there's redness and swelling and pain, that it's kind of quiet and you don't notice it, but it's creating this sort of smoldering fire.
And are you saying that most of this is coming from problems with our gut microbiome?
Environmental toxins.
So it's a total load effect that we've been talking about in our field for... So low-grade infections, like viruses, ticks, who knows what. It could be mold in the environment. Precisely. It could be our diet that's changing our microbiome and creating inflammation, sugar...
And so the question is... It's dealing with a bad set of circumstances.
I think that's what I've always said for years is that disease is just the body's best ability to deal with a bad set of circumstances. Change the circumstances and the disease goes away. That's right.
So this sort of takes us to the next little portal I want to dive into, which is so high level inflammation is basically the root of all evil in terms of chronic disease. We now can measure its effects through blood biomarkers, through epigenetic testing, which measures the control system on our genes and how it's turned on or off based on different influences.
And we can then intervene with lifestyle or different foods or phytochemicals to see how the biomarkers change and how our immune age changes over time.
Yeah, so we've never really, you know, it's one thing to say, okay, I'm going to give you a drug or some food and see if it prevents a heart attack 20 years from now. But what's happening underneath is this chronic low level of inflammation, all these cytokines and inflammatory cells, chronic
going awry leading to these chronic diseases, but we're seeing those changes happen far before you might have a symptom.
Most people don't necessarily have access to full epigenetic testing and deep analysis. And your company, Big Boat Health, which has pioneered a lot of the work around immunorejuvenation, understanding immunosenescence, immunometabolism, which we're going to talk about, has done deep analysis using special chips that look at epigenetics.
This is not something you can go just get from your regular lab. It's a pretty sophisticated test. But you were sharing with me earlier that there's some surrogate blood biomarkers that you can use that we test regularly to infer what's happening at the epigenetic level. So what are those?
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