Dr. Joseph Fraiman
speaker
522 appearances
2 recordings
1 series
first heard Dec 2025
last heard 4 Sep
Dr. Joseph Fraiman’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 2 in all, peaking in Sep 2026 with 1.
Appearances
And he gives very, you know, he gives specific ways that we can prevent this from happening.
And it's, we've always known how to do it.
And it's, we know that what you need, and he clearly demonstrates this is that we need randomized trials.
We can no longer be using surrogate markers such as, uh,
In vaccine trials, it would be antibodies.
They have to be clinical outcomes.
And is what he was saying, which means a surrogate outcome is a thing that
you would never know unless your doctor told it to you.
And what I mean by that is if you could take the surrogate outcome for any drug and cancer, for example, it would be how big is your tumor?
You have to get a CAT scan and then your doctor tells you your CAT scan is bigger and you're like, oh God, that's bad news.
So it seems logical that a drug that makes your cancer smaller
would be a good thing but actually surrogate markers are actually just sort of the first step in terms of figuring out if a drug works because you know how the drug you have an idea of how the drug works you need it to then do the surrogate it needs to change it needs to make the tumor smaller for example but if your tumor is smaller and then you die of liver failure that really doesn't matter right because the reason you're taking that cancer drug is to live longer
and so if you just are looking at the tumor size you're you're going to get it wrong because and the same is true with vaccines is that if you're only looking at antibodies or things that are you could even use a clinical outcome but if it's not a relevant one such as do you get a case of the sniffles that is actually going to if the answer if the reason for the vaccine is to prevent hospitalizations prevent death
If you don't do a study that shows it prevents hospitalizations or death, then we don't know if it reduced hospitalizations or death.
More importantly on that, you also need to make sure that it's doing it not on a cause-specific basis.
If it reduces COVID-19 deaths but then increases deaths in another place, that's not a thing that we want either.
we know this is not um new information that we i'm producing here for you that i've come up with a new way to do trials we've known this no for many years that this is how you determine if a drug is a good idea for human beings to take and our fda is supposed to allow only the ones through that
that are good for us.
And I believe that the FDA for a very long time has been failing at that.
And the COVID-19 vaccine, I believe, has brought attention to this problem to the general population in a way that...
Showing 341–360 of 522 · page 18 of 27
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