Dr. Jup Kuipers
speaker
284 appearances
6 recordings
1 series
first heard May 2026
last heard 9 Sep
Dr. Jup Kuipers’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 6 in all, peaking in Aug 2026 with 2.
Appearances
All right, everybody, this is the Health Optimization Medicine Podcast.
Your clinical team here today, myself, Dr.
Job Geipers, general practice physician in Amsterdam, and Home Doctor.
Boomer Anderson, our CEO of Home Hope and Health Optimization Medicine Practitioner, Dr.
Alan Bukats, Chief of Emergency Medicine and Home Doctor, as well, and Dr.
Theodore Achakoso, the founder of Health Optimization Medicine and
Practice, and Dr.
Schgott Scher, board certificated internal medicine doc and home doctor.
Today your clinical team is going after one question.
Can we reset epigenetic aging in an ApoE brain?
The next 25 minutes you'll get into the cellular mechanics, the clinical protocol, and the one thing most practitioners get wrong about this.
Let's go.
Alright, gents.
Can I get a
Let's trace the biology a bit.
So why is the APOE four brain metabolically and epigenetically more vulnerable, Doctor Ted?
So, circadian transcription factors like CLOC and BMAL1 drive the expression of NAMPT, the rate limiting enzyme in the NAD plus salvage pathway.
So when circadian rhythms are disrupted by late-night artificial light or shift work, NAMPT oscillations flatten.
Cellular NAD plus pools contract and CERT1 activity drops.
And these sartuans, they require NAD plus to regulate histone D acetylation and DNA repair, disrupt circadian timing, and you impair epigenetic maintenance.
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