Dr. Karan Rajan
speaker
2,601 appearances
14 recordings
1 series
first heard May 2026
last heard 7 Sep
Dr. Karan Rajan’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 14 in all, peaking in Jun 2026 with 5.
Appearances
So if we look at some of the data of people who are chronically overexercising, and by overexercising, that's a small percentage of the population who are maybe...
professional athletes or who are, you know, extreme iron man in the desert, you know, multiple times a month, you know, beyond what the body can do.
And that also comes with its own health risks, you know, rhabdomyolysis and thickening of the heart.
So I wonder whether there's a
a U-shaped curve similar with wealth as well, where clearly if you're at the bottom of society, the bottom of the socioeconomic status where you are maybe below the poverty line, your mortality is going to be the highest.
It drops as you get more money to a point, and then maybe the mortality goes up again to your point
as you have billions and trillions potentially, and you just don't know what to do with it, and you're seeking for something basically off the menu.
And when you pick something off the menu, there's a chance that whilst a one in a million chance it does make you live longer, it's probably got a significant chance of injuring you in the short term.
So it actually worsens your outcomes.
I think Brian Johnson is an example of this where...
in the peak of the rapamycin longevity drug craze, he was taking rapamycin as an N equals one and realized that was actually harming him.
And clearly that's not something the healthiest man in the world would do.
So I wonder whether there's a similar thing there where it's just like the poisons in the dose and the dose in this case could be money.
Yeah, I think the longevity enthusiasts, when they take it too far, they're probably guilty of, you know, something called reverse survivorship bias, where they are constantly looking at the outliers and they're cherry picking the data which suits them.
You know, instead of the typical survivorship bias where you're saying, my grandfather drank and smoked till he was 90 and never had lung cancer and liver problems.
And this side is saying, hey,
these mice did this and they lived longer than mice who didn't.
So we must all be doing this.
And I think there is, you know, probably some significant nuance lack there.
I guess when people are so bombarded these days on social media with all of these wild claims and supplements and products, what can someone do to buffer themselves against some of these grifty claims?
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