Dr. Karan Rajan

speaker

3,158 appearances 17 recordings 1 series first heard May 2026 last heard today

Dr. Karan Rajan’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 17 in all, peaking in Jun 2026 with 5.

Appearances

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Dr Karan Explores · Endometriosis Surgeon Explains What Everyone Gets Wrong - Dr Lora Liu · 13 Jul 2026 podcast

You know, uh there's often this myth that goes around, which might have a molecule of truth in it, that many people believe it's because of retrograde menstruation, where the menstrual blood refluxes back into the uh uterus and there's this backward flow, and that can cause the propagation of endometriosis, but 90% of women may experience voice-verified

Retrograde menstruation, but one in ten women have endometriosis. voice-verified

So there's a you know discrepancy between how many women experience retrograde menstruation and how many women are thought to suffer from endometriosis. voice-verified

So maybe that's a component driving it to some degree. voice-verified

But what really are the causes that we know of so far for endometriosis? voice-verified

The complexities of endometriosis are really epitomized by a lot of the things that you just mentioned there. voice-verified

You mentioned inflammatory component, the immune system being dysregulated, hematogenous spread, so spreading through the blood to other body parts, you know, genetic risk factors, you're born with it, maybe environmental triggers. voice-verified

I see a lot of people online sometimes comparing endometriosis with a cancer in terms of its etiology. voice-verified

In terms of how cancer spread, how aggressive they can be, how progressive they can be, how even despite surgery, it can still come back with recurrence, metastasis, how it spreads through the body via different routes, lymphatic, blood. voice-verified

I guess there are pros and cons for trying to draw similarities between something like endometriosis with something like cancer. voice-verified

But, you know, there are some similarities that I think are valid in terms of like, you know, the number of subtypes of endometriosis that we're beginning to understand that there are. voice-verified

You know, the sort of diagnostics are not always perfect. voice-verified

You know, you don't have blood tests always to detect cancer. voice-verified

Sometimes, you know, imaging studies may not detect cancer similar to endometriosis. voice-verified

Maybe one of the most similar things maybe we can apply that cancer model. voice-verified

To endometriosis, maybe in how it's generated, right? voice-verified

Like people, when you think about cancer, you talk about the traditional two-hit hypothesis. voice-verified

You may have like a genetic predisposition or a risk for cancer. voice-verified

Mm-hmm. voice-verified

And then in life, you get a second hit from an environmental trigger, which makes it worse or increases the risk further. voice-verified

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