Dr. Kent Berridge
speaker
525 appearances
1 recordings
1 series
first heard Aug 2026
last heard 4 Aug
Dr. Kent Berridge’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Aug 2026 with 1.
Appearances
At other moments, you want something else, a third thing.
The focus of wanting changes from moment to moment for most of us.
In addiction, the focus becomes sort of fixed and more intense for this one thing.
So what's controlling this focus, both in the natural situation and the addicted situation?
That's why we're doing the amygdala and mesolimbic.
Right.
Well, it's the dose.
The tiniest amount of the really potent ones, like some of the newer opioids that are coming along even more potent than others, even more potent.
You're right.
A tiny little crumb can kill.
But it's the dose.
I mean, if you could cut that crumb into smaller crumbs and just give the really small crumb, that wouldn't kill.
It's the dose.
The thing about opioids is that they activate the reward pleasure system very potently, yes, but they also simultaneously suppress the part of the brain that controls your breathing.
That's right.
Every breath we take is triggered by the brain.
It's commanded by the brain, a little nucleus in the brainstem, and opioids suppress that.
And the doses that are most enjoyed are the same doses that are becoming lethal.
you know, it would be great if the doses that were enjoyed were lower than the adult lethal doses, then people would take.
Yeah.
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