Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Huberman Lab · Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett · 25 Dec 2025 podcast

And that is improved if you are intermittent fasting.

So it's probably gonna help your growth hormone and subsequently IGF-1 levels, which will help more in older age groups than younger age groups.

There's still pretty good growth hormone output, even if you eat two or three hours before you sleep.

It's just the law of diminishing returns.

The longer you go, you get slightly more and slightly more.

But I think about it in terms of endocrine IGF-1, mostly IGF-1 that's synthesized in the liver and released in the liver.

versus IGF-1 that's released.

Classically, an example of this would be your IGF-1 levels increase after resistance training or exercise.

And that's more of like paracrine or autocrine, and they have more local action.

So that IGF-1, it's pretty well studied that if you just give people IGF-1, it's not going to, at physiologic levels, it's not gonna improve their body composition.

However, that IGF-1 that's autocrine and paracrine just working in those local tissues and muscles is likely part of the reason why you get a improved body composition response after exercise.

There's three big ones.

The first one is not super common, but it's a very direct correlation.

If you have a growth hormone deficiency, a true deficiency, whether you're an adult or a child, then your sleep is likely going to be affected.

And let's say you're a child with growth hormone deficiency.

Once that is replaced with therapy, your sleep is going to get significantly better.

The second one that's a very common scenario is if you're having what's called vasomotor symptoms of menopause or vasomotor symptoms of andropause, which are also applicable.

That's why a lot of women in menopause feel like their sleep is much worse, is because they have lower activity of those progestogens.

Low testosterone can lead to poor sleep, but my third scenario is actually if a man begins TRT.

then they develop a poor sleep because of sleep apnea.

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