Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Huberman Lab · Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett · 25 Dec 2025 podcast

It drastically raises the risk that somebody is going to have sleep apnea.

And then a lot of people, especially when they first started in the first month or two, it puts them into this hypersympathetic state because they have overactive androgen receptors, especially after a long time of being hypogonadal.

then they have a physiologic dose of TRT, and that causes the sleep issue itself.

If you're eugonatal before you start testosterone.

Meaning?

Meaning you have normal testosterone and then you start TRT or self-administered TRT, steroids, however you want to look at it.

then your risk of sleep apnea still goes up in a dose dependent fashion.

So the higher the dose, the more risky.

For health optimization, testosterone is just as important to know.

For pathology prevention, for example, breast cancer, osteoporosis, estrogen and progesterone are more important to know.

So when you're thinking about women, women think that they have such a tiny amount of testosterone because you test it.

Most people test a free testosterone.

So testosterone that's unbound, which is by far the smallest proportion of testosterone.

Any androgen is bound by lots of different steroid binding proteins, but the ones that are most pertinent are called SHBG or sex hormone binding globulin.

And that binds the androgenic steroid

for example, DHT or dihydrotestosterone, it's associated with prostate enlargement, it's associated with male pattern baldness.

It binds that the most strongly, and then it binds testosterone next most strongly, and then it binds things like androstenedione or DHEA, dehydroepiandrosterone.

and then it binds the estrogens, the weakest, like estradiol.

So if you look at the total amount of testosterone, women actually have, almost all women, not all women, but almost all of them have significantly more testosterone than estradiol, but it's because it's in different measurements.

So estradiol a lot of time is grams per mil as opposed to nanograms per deciliter.

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