Dr. Mike Roberts
speaker
1,217 appearances
1 recordings
1 series
first heard Jul 2026
last heard 8 Jul
Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
The total cell membrane protein pool significantly increased, which I thought was cool.
I looked at the literature and said, oh, wow, this is kind of the first time that we're saying,
things that happen at the cell membrane.
Maybe important to know, by the way, from cell membrane down to signaling to muscle protein synthesis is important, right?
The transduction of the mechanical tension down to the ribosome in terms of increasing protein synthesis.
So Josh did proteomics on that, and we found a couple of proteins, one of which was called vimetin, V-I-M, that
We saw small sample size regression seemed to be associated with mild fibrohypertrophy.
We did some elegant studies showing that vimentin seems to, it's an intermediate filament, meaning that it should exist in cells, but what we found was it seems to be deposited in the extracellular matrix.
And it seems to come from satellite cells.
Like, I don't know if the satellite cells secrete it.
We didn't answer that question.
But we saw, using John McCarthy's PAC-7 DTA model of satellite cell ablation or getting rid of satellite cells in a mouse, we got rid of satellite cells and applied mechanical overload.
We didn't see vimentin in the extracellular matrix, hardly at all.
And they didn't hypertrophy as well.
Now, there's other factors that play into that mouse model.
The lack of satellite cells prevents myonuclear accretion.
So that certainly is also driving that lack of hypertrophy.
But it is coinciding with the loss of VIM being associated with hypertrophy.
So we think.
more research needs to be done from VIM.
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