Dr. Mike Roberts
speaker
1,217 appearances
1 recordings
1 series
first heard Jul 2026
last heard 8 Jul
Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.
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Yeah.
Okay.
So golly, myostatin.
John Petrilla was a PhD student with Marcus and that early landmark, again, landmark hypertrophy molecular paper by J. Kim and Marcus showing modest, low, extreme responders to 16 weeks of training in terms of muscle fiber CSA increases.
One thing that they showed was
was that myostatin signaling pre, post-intervention, I believe, I'll have to go back and look at this in detail,
there were differences between extreme and low responders, which is to say that the myostatin response seemed to be partly diminished in those extreme responders.
We have since taken an interest in myostatin.
I mean, golly, right, if you overexpress folistatin, which inhibits myostatin in a mouse, or if you knock out myostatin genetically, or if you have this
selectively bred dog or Belgian blue cow that has a mutation in myostatin and therefore doesn't have a functional myostatin protein, they are jacked.
They are completely yoked.
Yeah, the German, I think, child that we've all lost touch of.
Okay, all right.
Yeah, in humans too.
You have CRISPR-Cas9.
growth right and i think uh even though you're gonna hear me say this i always catch things on we we always need a little bit more data yeah just to be more certain yeah right because i want to speak truths and i don't want to you know um spread falsehood based on the john petrella data um as well as just data showing that when you resistance exercise
You are down-regulating myostatin at the mRNA level.
You are up-regulating folistatin, which is the inhibitor of myostatin at both the mRNA and protein level.
We have a 2023 paper of Mason McIntosh showing that.
The pathway is certainly a conserved response to a bout of training.
Showing 421–440 of 1,217 · page 22 of 61
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