Dr. Mike Roberts

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1,217 appearances 1 recordings 1 series first heard Jul 2026 last heard 8 Jul

Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Perform with Dr. Andy Galpin · What Drives Muscle Growth & What Doesn't | Dr. Mike Roberts · 8 Jul 2026 podcast

A lot of people have done transcriptomics because they've been intrigued with the notion that when we have mechanical tension with resistance training, we see a huge sledgehammer effect on the gene changes at the mRNA level.

And so that's just naturally where the field has gravitated.

hardly anyone was doing proteomic work.

And so I really wanted to sort of pound that drum hard because I said, well, this is a knowledge gap opportunity.

And oh, by the way, we have a really nice collaborator on campus that does this work.

And she's excited that we give her human muscle.

What we are seeing, Andy, is this, the young cohort on average, apologies if I misquote this when you see the publication,

But the muscle proteome is changing robustly in the young cohort, which coincides with the enhanced hypertrophy.

Yeah, turnover of proteins, expression of new mRNAs where you have the production of new proteins at a higher level that weren't there prior to training, okay?

That coincides.

Yes.

And oh, by the way, when you run that protein list of what changed in the young people, a lot of those proteins are related to proteostasis, which works to that mechanism that you just spoke of.

There is a lack of proteome plasticity.

in older people, which coincided with the diminished hypertrophy.

So that is going to be probably, if not the title of the paper, we need to pay attention to this.

We're not seeing enzymatic changes with resistance training.

We're not seeing much by way of proteins that are ribosomal proteins, for instance, with resistance training.

Stuff that we're seeing in the younger people, we're not seeing in the older people.

Why is that?

Don't know, except to say perhaps.

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