Dr. Mike Roberts

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1,217 appearances 1 recordings 1 series first heard Jul 2026 last heard 8 Jul

Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.

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Perform with Dr. Andy Galpin · What Drives Muscle Growth & What Doesn't | Dr. Mike Roberts · 8 Jul 2026 podcast

So all 23 cells.

chromosomes, over 20,000 genes that are protein coding, et cetera, inside of that nucleus, inside of that cell.

Muscle cells, and you've done a lot of work in this, right?

If you image them under a microscope individually, you will see very, very long cells, and you will see that the nuclei are on the

of the cell, which is unique.

And one of the sort of predominant theories in our field is we have this

myonuclear governance of cell size.

And so in order for that cell to grow, right, we need to add more myonuclei to regulate certain areas of that muscle cell in order to make mRNAs, which then are translated into proteins.

And then you can have the deposition of those proteins, be it into the contractile apparatus.

You can have metabolic enzymes residing in that area of the myonucleus, etc.,

But if you close your eyes and just think spaghetti noodle, and you take a sharpie, a fine sharpie marker, and just draw dots on that, those would be each of the malnuclei, right?

As you lift weights, right, just imagine the diameter of that spaghetti noodle increasing in size, and you draw more dots on that spaghetti noodle, right?

Yeah.

People then ask, well, where do those nuclei come from is a natural question.

And by and large, they come from muscle stem cells or satellite cells.

One good stimulus to activate satellite cells so that they fuse to that growing fiber is resistance training.

Just tried and true, certainly a conserved mechanism, whether it be a rodent or human, we're going to activate satellite cells to eventually fuse to those growing mob fibers with resistance training.

Now, inside the cell, you had said, you know, what are the sort of nuance components?

You're going to have 80 to 85% of that cell volumetrically occupied by myofibrils.

I'm trying to go back to the spaghetti noodles.

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