Dr. Mike Roberts

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1,217 appearances 1 recordings 1 series first heard Jul 2026 last heard 8 Jul

Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Perform with Dr. Andy Galpin · What Drives Muscle Growth & What Doesn't | Dr. Mike Roberts · 8 Jul 2026 podcast

So we wrote this review article, Paulo Mesquita, who did that 14-week endurance training or resistance followed by endurance.

He wrote a very nice review article about

trying to find all of the papers that have done resistance or endurance training or even concurrent training, looking at what happens with ribosome markers from biopsies and what happens with mitochondrial markers.

And the short answer is, uh,

Anything you can imagine happens, happens.

Some studies, by and large, resistance training will increase more of the ribosome biogenesis than the mitochondrial biogenesis stuff.

However, acutely, PGC-1-alpha is activated in terms of mRNA expression, even phosphorylation of the protein.

with a bout of resistance exercise, dude.

Yeah.

And then same could be said on the other end of the equation, where if you do this endurance exercise bout, albeit it's a little bit less, there's less of an effect there with the ribosome stuff.

Like if you do one bout of treadmill running, and Andy, I get your biopsy pre and post,

You're not going to see ribosome biogenesis markers move the needle.

We've shown that endurance exercise doesn't seem to stimulate ribosome biogenesis.

Certainly does, though, increase capillarization, increases mitochondrial biogenesis.

But resistance exercise is more complex.

And that's probably...

volume load dependent, which is to say, if you do a high volume training set, now you're sort of getting into this muscular endurance aspect that starts triggering some of those pathways, more so than just doing like, you know, sets of three, which probably doesn't touch those pathways, right?

That resistance training is bad for mitochondria?

Correct.

Oh.

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