Dr. Scott Sherr
speaker
1,547 appearances
17 recordings
1 series
first heard May 2026
last heard 3d ago
Dr. Scott Sherr’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 17 in all, peaking in Sep 2026 with 4.
Appearances
More gas does not release the parking brick.
to war is finally over, man.
Take care everybody.
And welcome back to the Health Optimization Medicine Podcast.
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So today your clinical team is going after one question.
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Can a single dose of creatine monohydrate rescue a sleep deprived brain?
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In the next 25 minutes or so, you'll get the cellular mechanism, the clinical protocol, and the one thing most practitioners get wrong about it.
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Let's go.
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Well, let's pause here for a second because as an internist, this is incredibly fascinating.
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Under normal non-stress physiologic conditions, the blood-brain barrier is highly restrictive to creatine.
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The brain synthesizes its own creatine endogenously via AGAT and GAMT enzymes.
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Getting peripheral creatine into the brain typically requires a loading phase of 20 grams a day for a week.
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But what this research reveals is that the sleep deprivation is not just being tired.
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It is acute bioenergetic stress that disrupts blood-brain barrier permeability
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and increases the activity of the SLC6A8, the sodium and chloride dependent creatine transporter.
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The acute stress opens the window for a single low dose rescue.
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The protocol is elegant because of its simplicity and accessibility.
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It's literally a one-cent solution.
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Dr. Ted's fond of those.
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Based on the 2026 nutrient paper and the 2024 scientific reports data, the therapeutic window for acute brain rescue is the following.
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Showing 281–300 of 1,547 · page 15 of 78
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