Dr. Stephen Klein

speaker

550 appearances 1 recordings 1 series first heard Jun 2026 last heard 25 Jun

Dr. Stephen Klein’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jun 2026 with 1.

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That's called 3.7.

The numbers don't really matter.

But when I meet somebody, my first job as an addiction medicine doctor is to stage the severity of their use.

So I ask them the 11 DSM criteria.

By that, they can be mild, moderate, or severe.

After that, I really offer everyone with opioid use disorder buprenorphine products when they're at my level of care.

They are the gold standard.

I think they're incredible.

The way that we judge effectiveness of medications is something called NNT, number needed to treat.

That's the number of patients who must receive a medication for one patient to have a benefit.

The number needed to treat for buprenorphine is somewhere between two and three.

Very, very high effective, very, very low number needed to treat.

Now, Trexone for opioid use disorder and alcohol use disorder is about 12.

Still pretty good for context.

The number needed to treat for something like statins to avoid one cardiovascular event over a five-year period ends up being greater than 30.

So we're getting a much bigger effect.

These medications really are amazing.

And when I'm sitting with somebody in my office, I really tell them, you have a life-threatening condition, which is opioid use disorder.

I have a medication that can treat that.

Unfortunately, that's not where the conversation stops.

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