Dr. Stephen (Steven) Klein

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467 appearances 1 recordings 1 series first heard Jul 2026 last heard 2 Jul

Dr. Stephen (Steven) Klein’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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RECOVERable: Mental Health and Addiction Experts Answer Your Questions · Ozempic and Cravings: How GLP-1 Drugs Work for Addiction · 2 Jul 2026 podcast

So when I talk about the rewiring of the brain, it's really to relearn to not be on a battlefield.

It's to re-equilibrate our hearing so that we can hear the tinkering of bells.

If you're used to only the input of drugs giving you the dopamine necessary to feel even normal, what chance does a good conversation with a friend stand?

Or the sunlight on your face, seeing someone that you love after a week of them being away.

Those things are smaller, more nuanced dopamine signals.

I think abstinence is the gateway to relearning that actually life is full of beautiful things and wonder.

When we're in the depths of our addiction, we forget that.

We don't yet know.

We can only say what the data shows.

So the data right now for GLP-1s, there's two main categories of data.

One is observational and the other is prospective.

For observational studies, we have huge, I'm talking hundreds of thousands of patients in big healthcare systems that are prescribed these for either weight loss or type 2 diabetes, and then we make retrospective observational accounts of what's happening.

In those studies, the biggest ones that have emerged are opioid use disorder, alcohol use disorder, and nicotine use.

Then prospectively, that's when we take patients and randomize them to either get semaglutide, ozempic, or placebo.

That's kind of the gold standard of medical interventions.

Those are emerging the most, in my opinion, the strongest evidences in alcohol use disorder.

It's what affects the most people and what's easiest to fund.

So from that perspective, it's where the data is.

Mm-hmm.

Again, this larger study that came out that was actually 600,000 US veterans showed an effect across so many substances that I think we're just scratching the surface.

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