Dr. Stephen (Steven) Klein

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467 appearances 1 recordings 1 series first heard Jul 2026 last heard 2 Jul

Dr. Stephen (Steven) Klein’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Yeah, so in a very kind of simple way, I think when we talk about GLP-1s, we have to talk about three organ systems.

First organ system is the pancreas.

In the pancreas, they basically increase the release of insulin.

That treats type 2 diabetes pretty straightforward.

In the stomach, it's a second organ system.

They decrease gastric emptying.

So it's delayed gastric emptying, slows the transit of food.

People feel full longer, weight loss.

Now let's talk about the brain.

The brain is really where I spend a lot of my time thinking.

It's fascinating because like, you know, in every other disease model, we talk about the organ and we talk about the pancreas and diabetes.

We talk about the stomach and obesity and addiction.

For some reason, we've always talked about the whole person.

You are the person.

It's your issue.

It's not.

It's a disease of the brain.

And the fact that all of the brain regions that control addiction, the mesolimbic system, again, have GLP-1 receptors.

And we know now because of the rodent evidence, the animal models, that

Using GLP-1s modulate that system in such a way that could be beneficial for addiction.

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