Dr. Tommy Wood

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1,133 appearances 1 recordings 1 series first heard Jul 2026 last heard 20 Jul

Dr. Tommy Wood’s voice in public audio — every appearance, attributed to the second.

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Huberman Lab · Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood · 20 Jul 2026 podcast

Alzheimer's disease is the most common.

It makes up about 60 to 80% of cases of dementia.

The next most common is vascular dementia, although vascular dementia and Alzheimer's disease overlap a ton.

The vast majority of people who have Alzheimer's disease also have some element of pathology or changes in the blood vessels in their brain, which is what you get with vascular dementia.

And then there's also dementia with Lewy bodies, frontotemporal dementia, and then dementia related to Parkinson's potentially, although that overlaps a lot with

Lewy body dementia.

And dementia in Parkinson's may actually mostly be Lewy body dementia.

But we've gotten to a point now where it's generally accepted that potentially half of cases of dementia are preventable.

And I think the majority of that falls into those first two buckets, Alzheimer's and vascular dementia.

Although metabolic disease and other risk factors for Alzheimer's disease also increase the risk of Parkinson's disease and those other dementias as well.

When you then think about Alzheimer's disease specifically, there's one small slice of Alzheimer's, which is like monogenic dominant mutations that you have in either, most of them happen either in the presenilin genes, presenilin 1 and 2, or the amyloid precursor protein gene.

They make up

At this point, less than 5% may be as little as 1% of Alzheimer's disease.

So we set those to the side a little bit.

The vast majority of Alzheimer's disease is what we would call late onset Alzheimer's disease, although it's happening actually earlier and earlier in some populations.

Yes, there's a genetic component.

Your APOE gene is probably your most common risk gene.

There's also polygenic risk, so thousands of genes can give you a little bit more or a little bit less risk of Alzheimer's disease.

But it's much more related to lifestyle and the environment than, say, that early onset monogenic Alzheimer's disease.

The best accepted

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