Dr. Tony Wyss-Coray
speaker
644 appearances
1 recordings
1 series
first heard Feb 2026
last heard 23 Feb
Dr. Tony Wyss-Coray’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Feb 2026 with 1.
Appearances
We took this to the next level and asked,
Can we build similar models and estimate how old cells are in your body?
So we have many different cell types, right?
That's how we have specialized organs.
So we were able to, with the current technology that measures these thousands of proteins, we were able to assign proteins to 40 different cell types.
And so we can now make estimates of specific cell types in your body.
One of the most striking findings was
We looked in people with different neurodegenerative diseases and asked, how old are all their different cell types?
And we find in this rare disease called amyotrophic lateral sclerosis, or ALS.
In the US, we often call it Lou Gehrig's disease, because Lou Gehrig was this baseball player who got this devastating disease.
It's a muscle weakness that often progresses extremely quickly and people die.
And what we found is that these individuals had an enrichment in extremely old muscle cells, skeletal muscle cells in particular, and also heart muscle cells, cardiomyocytes.
So there was this very strong association.
And then we looked in a longitudinal study
cross-sectional, but where we had 20 years follow-up.
It's called the UK Biobank.
So we had blood samples from people when they entered their study healthy.
And then a number of people developed, about 250 developed ALS over the course of 15 years.
And we found a strongly increased risk to develop the disease if they had these extremely old muscle cells.
So here we have now a much...
Showing 601–620 of 644 · page 31 of 33
← Previous
Next →