Dr. Tony Wyss-Coray
speaker
644 appearances
1 recordings
1 series
first heard Feb 2026
last heard 23 Feb
Dr. Tony Wyss-Coray’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Feb 2026 with 1.
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finer resolution and granularity where we can get more predictive power.
We can get more precise prediction of what type of disease you might get.
And of course, at the molecular level and the cellular level, we know where the problem might be, right?
It's not just the whole organ, but now we know which cell type.
Another one was there's these cells we call astrocytes in the brain.
We find a very strong association of the age of astrocytes and development of Alzheimer's disease, much stronger than just the brain age, so the age of your whole brain.
When we look now at these individual cells, they are a very strong predictor of Alzheimer's disease, especially together with a genetic risk factor.
So that's...
something that we have been developing and really excited about but my ultimate greatest stimulation right now is to build a map of the human proteome across different genetic diseases so what i'm trying to do is to ask if somebody has a disease
that is caused by a single genetic mutation.
And there's about six, 7,000 such, we call them monogenic diseases, where if you have a mutation, you will get a disease, childhood disease or an adult disease.
So what I want to do is to look at individuals with these mutations and profile their plasma, basically measure all the proteins and see, are they different from healthy people?
And if you do that across hundreds of diseases, you basically get a picture of how our body responds to the disruption of specific genes.
And the idea is that this will allow us to look at any type of disease where we don't know how it's caused and then say, this looks like this genetic disease.
Basically what we've been doing in animals
with worms, right, where we knock out every gene, or in flies, use the human
experiment, if you will.
And this may be a bit disparaging.
These are obviously people who have diseases, but there are repositories where people volunteer to make these samples available for research.
And so we have had the opportunity already to look at 25 different genetic diseases and we find these very specific patterns.
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