Eric Topol

The demonization of hormone replacement therapy for perimenopausal women and the undercreation of its health benefits ranks among the greatest mistakes of modern medicine.

And then the other one in JAMA, which is kind of in the same category,

With the exception of antibiotics and vaccines, there may be no medication in the modern world that can improve the health outcomes of older women on a population level more than hormone therapy.

What did you think about that?

Yeah, so speaking of stuff, there were two trials in WHI.

One, of course, was with the combination.

And then the other, smaller but still, I think, important, 10,700 women randomized to estrogen alone versus placebo.

And they had very different results.

whereby you say, hmm, is this the estrogen?

Is it the hit of the dual hormone?

How did you interpret all that?

Right.

No, it's very clear from both the JAMA and the Wall Street Journal article, as you said, these were picking specific interpretations of, you know, ice pick views of certain data like the cognitive benefit and whatnot.

But the other thing, of course, that the WHI enrolled older women.

you know, well beyond the average age of menopause, 51, I guess.

And they could have been more than 10 years out.

So you just wonder in this population back from 20 years ago, they reported on plus 22, 23 years ago, that they were picking out on a study that this was preventive treatment rather than symptomatic treatment and the wrong women.

But I guess it would be from that, what you just said, we don't really have a trial that

with the modern preparations in women who are within 10 years and 60 years old from menopause, you know, we don't have a real prospective randomized child, right?

Okay, I'll accept that.