Eric Topol

And we're going to test...

for the first time in this large-scale study, the lifestyle factors, the exercise, the sleep, the diet, and the stress in a coached group, intensive coaching, versus a group that just gets some educational material.

And then after that, we'll start looking at different drug candidates on top of lifestyle, assuming that we show and validate that that makes a difference

in these markers like the brain aging clock and the P tau 217, which are really reliable ways to project the arc of a person's Alzheimer's risk.

So we're in a new day.

I'm curious.

Oh, yeah, yeah.

So they get 24-7 virtual and human coaching.

Basically, for all lifestyle factors, they're going to get continuous aggressive coaching with human backup for questions and encouragement.

And we're able to dissect how much of the benefit, assuming there is, is related to exercise.

How much of it's due to sleep and on and on.

These all be quantified.

And for each individual.

Exactly.

Right.

And one thing that's really important that I think you've touched on, when we tell the whole world this is what you should be doing, it doesn't really get a lot of uptake and respect.

But when we talk to an individual and we define precisely what their risk is and when it might show up, the chance of them making some changes...

in their lifestyle, which we know has impact, is much, much greater.

Everything has to work at the individual level.

Population-level messages just don't have that kind of impact.