Erin Allman‑Updyke and Erin Welsh

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988 appearances 1 recordings 1 series first heard Aug 2026 last heard 4 Aug

Erin Allman‑Updyke and Erin Welsh’s voice in public audio — every appearance, attributed to the second.

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This Podcast Will Kill You · Ep 218 The Lowdown on Statins · 4 Aug 2026 podcast

And so that might differ in how much they build up in different tissues in your body.

But there's not great data that says that one is more or less likely to cause side effects than the other.

And that's the next thing I want to briefly talk about because it's an important part of the statin story.

And you mentioned it as well, Erin.

It is not the case that side effects don't exist.

Right.

Any medication, any therapy, really, has the potential to cause side effects.

And like you mentioned, Erin, the most cited side effect that causes people to stop taking a statin medication is muscle symptoms.

And that's a really general term.

It's often muscle pain or muscle aches or sometimes muscle weakness.

Now, there's also other things like gastrointestinal side effects or liver enzymes can increase, which is usually transient and can be completely reversed either by going down on the dose or stopping the statin.

But muscle effects are like the big one, right?

And there was a recent meta-analysis that looked at data from randomized controlled trials from over 150,000 people and 23 different studies that were comparing either statins versus placebo or different intensities of statins.

So that high intensity versus low intensity therapy.

And what they found is not that muscle symptoms were never reported by any means, but that by comparing all these different regimens, what they estimated was that less than 10% of all of the reports of muscle symptoms could actually be directly attributed to statins themselves.

Does that make sense?

I think so.

So it's not talking about the rate of side effects that happen.

No, mm-mm.

how much of those side effects are statins directly responsible for?

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