Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh

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917 appearances 1 recordings 1 series first heard Jul 2026 last heard 28 Jul

Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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This Podcast Will Kill You · Ep 217 The High Stakes of Cholesterol · 28 Jul 2026 podcast

And then as these plaques build up and our body is trying to respond to it, eventually we build this kind of fibrous cap over it.

Our smooth muscle cells build a cap and eventually they calcify.

And that's all our body's response to try and stop this thing that's in the walls of our blood vessels from taking over, essentially.

Okay, so it's essentially a numbers game in that, you know, we can throw things like the LDL receptors in there, we can throw, but ultimately it comes down to how much LDL is in your bloodstream that is not being taken up by cells for whatever reason.

And that just is associated with more of these little clogs, these little sort of sticking to the walls of your arteries.

And then that cholesterol leaking out into the actual lining, causing inflammation and an immune response, which then leads to hardening and plaques, et cetera, and problems down the line.

Exactly.

Or immediately.

Yeah.

So those problems could be that the plaque gets so big that it actually blocks the vessel entirely.

Or it could be that the plaque gets big and then becomes unstable and a chunk of it breaks off, travels farther down, and blocks smaller arteries.

Okay.

That's cholesterol and how it causes atherosclerosis.

That's as short as I could make it, Erin.

Tell me about the relationship between LDL and things like age, things like diet.

I know you mentioned saturated fats, but like, and you said we don't know the mechanism.

And then also some hard numbers here.

Like what levels are we talking about?

And what is important to consider?

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