Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh
speaker
917 appearances
1 recordings
1 series
first heard Jul 2026
last heard 28 Jul
Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
Yeah, wow.
But increasingly, those cholesterol doubters were becoming a tiny but vocal minority.
Other studies, such as dietary intervention studies, helped to build the case against cholesterol, but there was still one important facet missing, and that was a mechanism.
Mm-hmm.
So since at least the late 1800s, physicians had noticed a condition that ran in some families where people developed large deposits of lipids under their skin.
Members of these families were very prone to develop severe cardiovascular disease at early ages, with some experiencing heart attacks in the first 10 years of life.
And by the early 1970s, researchers had established that very high blood cholesterol was a key feature of this, hence the name familial hypercholesterolemia.
But they weren't sure what caused it or its role in disease development particularly.
They were like, okay, there's clearly a genetic link, but what's the mechanism here?
What is that mutation that leads to these high cholesterol levels?
What is going on that is causing this person's cholesterol to be so high and then resulting in negative health outcomes?
Why?
Why?
Why?
Why?
In 1973, the key to the puzzle was unlocked by two researchers, Michael Brown and Joseph Goldstein, who over the course of their 50-year collaboration would be compared to Rodgers and Hammerstein.
Wow.
Which is so, I love that.
Yeah.
Erin, can we work together for 50 years?
Showing 801–820 of 917 · page 41 of 46
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